Mukherjee’s Equation: An Equation to Calculate GFR of an Obese Asian

DATTATREYA MUKHERJEE

Cite this article as: Mukherjee D. Mukherjee’s Equation: An Equation to Calculate GFR of an Obese Asian. Int Healthc Res J. 2021;5(7):LE1-LE2. https://doi.org/10.26440/IHRJ/0507.10437

Author Affiliations:

Intern, First Affiliated Hospital of Jinan University, Guangzhou, P.R China (https://orcid.org/0000-0001-7566-3843)

Contact Corresponding Author at: dattatreyamukherjee4u[at]outlook[dot]com

INTRODUCTION

Dear Editor,

Glomerular Filtration Rate [GFR] is an essential value to understand the condition of two kidneys.¹ Currently we are using different formulas to calculate it. One of the formulae is 1973s Cockcroft-Gault formula.² The formula is:

CCr={[140-age] x wt}/S.Cr x 72

Wherein
• CCr (creatinine clearance) =mL/minute, this reflects the GFR
• Age = years
• Weight = kg
• SCr (serum creatinine) = mg/dL

Currently the most used formula is 2009 CKD-EPI creatinine equation^₃ which has parameters like SCr, Age, Gender, Race.

Now, I have studied and realized that we are missing with an important factor, that is height which is a very important demographic factor. Several studies have shown that BMI is inversely proportional to GFR.⁴ So, after calculating I am proposing an equation which has height as a measuring factor. This equation will be called Mukherjee’s equation. The equation is:

GFR =[2100-age]/[0.72 x S.cr x BMI]

Wherein:
• BMI=Weight in Kg/Hight in m2
• Age in years
• S.Cr in mg/dl

Points to be noted:
1. This formula is for Asian patients
2. Age is more than 18 years
3. Only for obese patients, BMI>30
4. For female, the value will be multiplied by 0.8

I am proposing this equation and, in my calculation, I have found some differences with the conventional one. I believe this equation will give more precise result than the conventional one. Through this equation, I have tried to create a bridge between Cockcroft and 2009 CKD-EPI. Although, a clinical trial is needed to validate this equation. Through this article, I am first proposing my equation, Mukherjee’s Equation in front of the scientific world.

REFERENCES
1. Medline Plus. Glomerular Filtration Rate, US National Library of Medicine (Online Article). Available from: https://medlineplus.gov/ency/article/007305.htm [Last Accessed on 15th August, 2021]
2. National Kidney Foundation. Cockroft Gault Formula. (Online Article). Available from: https://www.kidney.org/professionals/kdoqi/gfr_calculatorcoc. [Last Accessed on 25th June, 2021]
3. Da Vita. Glomerular Calculator. (Online Article). Available from: https://www.davita.com/tools/gfr-calculator. [Last Accessed on 25th June, 2021]
4. Kawamoto R, Kohara K, Tabara Y, Miki T, Ohtsuka N, Kusunoki T, Yorimitsu N. An association between body mass index and estimated glomerular filtration rate. Hypertens Res. 2008;31(8):1559-64. doi: https://doi.org/10.1291/hypres.31.1559.

Dattatreya Mukherjee. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY-NC 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the use is not commercial and the original author(s) and source are cited.

Submitted on: 11-Jul-2021; Accepted on: 12-Oct-2021