Muscular Adverse Events Associated with Statins

  • Reena Royal
  • Nuwan Jayawardene
Keywords: Statins, Myalgia, Side Effects


Statins are an important group of lipid lowering medications that have helped to control cardiovascular mortality globally. Muscular side effects, mostly myalgia, is a known adverse event of statins. Intense physical activity, kidney or liver failure, hypothyroidism, inherited or metabolic myopathies, and some medications, are risk factors for statin-induced myalgia. Muscular adverse events are more often observed with higher doses or with the use of lipophilic statins. Much is not known about the precise mechanisms responsible for the statin related muscular adverse effects, a few hypothesis have been suggested. It is important to measure plasma creatine phosphokinase in subjects who encounter myalgia while being treated with statins. In this review we present some general safety information on muscular adverse events caused due to statins.


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Author Biographies

Reena Royal

MD (Internal Medicine), Practicing Medical Specialist, Lumbini, Nepal

Nuwan Jayawardene

B.Sc. Nursing, Mankulam, Sri Lanka


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DOI: 10.26440/IHRJ/0505.08442
Published: 2021-08-28
How to Cite
Reena Royal, Nuwan Jayawardene. Muscular Adverse Events Associated with Statins. IHRJ [Internet]. 2021Aug.28 [cited 2024Jul.15];5(5):RV5-RV7. Available from: