Curcumin: A Review of Its’ Effects on Human Health

  • Sanjana Seth
  • Kashmeera Agarwal
  • Abdul Rahman
Keywords: Curcumin, Cancer, Arthritis, Antioxidant


Turmeric, commonly referred to as “Indian saffron” or the “golden spice”, is a rhizomatous herbaceous perennial plant (Curcuma longa) and belongs to the ginger family. Spices made from the ground roots of the plant are available commercially. It has been used an active ingredient for formulating various medicinal preparations, and finds regular use in Ayurveda and Chinese medicine. Turmeric,  and its constituent ingredients are being considered as multitargeted phytochemicals in the treatment of cancer as cell functions like apoptosis, autophagy, and cell cycle arrest are affected by its use. It has been shown to improve systemic markers of oxidative stress  and its effect on free radicals is carried out by several different mechanisms. This brief review discusses the health benefits of curcumin as well as its medicinal use.


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Author Biographies

Sanjana Seth

M.Pharm, Clinical Research Associate, Moga, Punjab, India

Kashmeera Agarwal

M. Sc. (Microbiology), Clinical Research Associate, Moga, Punjab, India

Abdul Rahman

B.Pharm, Independent Researcher, Pabna, Bangladesh


Wilson DR. The positive and negative health effects of turmeric (Online Article). Available from [Last Accessed on 12th September, 2021 ]

Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017;6(10):92.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1): 195-218.

Gera M, Sharma N, Ghosh M, Huynh DL, Lee SJ, Min T, Kwon T, Jeong DK. Nanoformulations of curcumin: an emerging paradigm for improved remedial application. Oncotarget. 2017; 8(39):66680-98.

Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA. The Essential Medicinal Chemistry of Curcumin. J Med Chem. 2017;60(5):1620-37.

Delgado-Vargas F, Paredes-López O. Natural Colorants for Food and Nutraceutical Uses, CRC Press, Boca Raton, FL, USA, 2002.

Zhu Y, Bu S. Curcumin induces autophagy, apoptosis, and cell cycle arrest in human pancreatic cancer cells. Evidence-Based Complementary and Alternative Medicine 2017;2017:5787218.

Ahmad RS, Hussain MB, Sultan MT, Arshad MS, Waheed M, Shariati MA, et al. Biochemistry, Safety, Pharmacological Activities, and Clinical Applications of Turmeric: A Mechanistic Review. Evidence-Based Complementary and Alternative Medicine 2020;2020: 7656919.

Chen MJ, Cheng YM, Lai PH, Wu JF, Hsu YC. In vitro biocompatibility of thermally gelling liquid mucoadhesive loaded curcuminoids in colorectal cancer chemoprevention. International Journal of Colorectal Disease 2012;27(7):869–78.

Yu J, Zhou X, He X, Dai M, Zhang Q. Curcumin induces apoptosis involving bax/bcl-2 in human hepatoma SMMC-7721 cells. Asian Pac J Cancer Prev, 2011;12(8):1925–9.

Lee SJ, Langhans SA. Anaphase-promoting complex/cyclosome protein Cdc27 is a target for curcumin-induced cell cycle arrest and apoptosis. BMC Cancer 2016; 12(1):44.

Nair KL, Thulasidasan AK, Deepa G, Anto RJ, Kumar GS. Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier. Int J Pharm. 2012 Apr 4;425(1-2):44-52.

Yin H, Guo R, Xu Y, Zheng Y, Hou Z, Dai X. Synergistic antitumor efficiency of docetaxel and curcumin against lung cancer. Acta Biochimica et Biophysica Sinica, 2012; 44(2):147–53.

Kuo CL, Wu SY, Ip SW, Wu PP, Yu CS, Yang JS, et al. Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signalling responses. International Journal of Oncology 2011;39(2):319-328.

Sahebkar A, Serbanc MC, Ursoniuc S, Banach M. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. J Funct Foods. 2015;18:898–909.

Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105–125.

Priyadarsini KI, Maity DK, Naik GH, Kumar MS, Unnikrishnan MK, Satav JG, et al. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic Biol Med 2003;35:475–84.

Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016 Aug;82:578-82.

Sahebkar A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil Steril. 2010;94:


Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52(2 Suppl 1):55-62.

Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016 Aug;19(8):717-29.

Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012 Nov;35(11):2121-7.

Bradford PG. Curcumin and obesity. Biofactors 2013;39:78–87.

Kocaadam B, Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 2017 Sep 2;57(13):2889-2895.

Lao CD, Ruffin MT 4th, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006 Mar 17;6:10.

Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, Pirmohamed M, Gescher AJ, Steward WP. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance. Clin Cancer Res. 2004;10(20):6847-54.

DOI: 10.26440/IHRJ/0510.01486
Published: 2022-01-29
How to Cite
Sanjana Seth, Kashmeera Agarwal, Abdul Rahman. Curcumin: A Review of Its’ Effects on Human Health. IHRJ [Internet]. 2022Jan.29 [cited 2024Apr.14];5(10):RV1-RV4. Available from: