A dentigerous cyst is a developmental cyst of odontogenic origin which develops around the fully-formed crown of an unerupted tooth. The significance of keratinization in odontogenic cysts is not fully known, but keratinization is the final product of epithelial cell differentiation. However, dentigerous cysts, thought to arise from reduced enamel epithelium, are products of end cells, i.e. cells that have completed synthesis (enamel formation). It is possible that the dentigerous cyst is a primordial variant, arising from more primitive cells of the developing enamel organ.