Poor Prognosis Factors of Severe Malaria in Antananarivo, Madagascar

Les Facteurs De Mauvais Pronostiques Du Paludisme Grave a Antananarivo, Madagascar

  • Jasper Grant Raelison
  • Hanitra Mbolatiana Rivoarimanana
  • Tanjonirina Razafindrainibe
  • Nadia Marie Philibertine Rahanitriniaina
  • Falihery Albertin Rakotomavo
  • Nasolotsiry Enintsoa Raveloson
Keywords: Intensive Care Unit, Mortality, Poor Prognosis Factors, Severe Malaria

Abstract

INTRODUCTION & AIM: Malaria is a major health problem in our country. Our aim is to determine the poor prognosis factors of this pathology.
MATERIALS AND METHOD: A retrospective descriptive, analytical study was conducted in the intensive care unit of University Hospital Center of Joseph Raseta Befelatanana, during 24 months (June 2015 to May 2017). The severity was defined according to the recommendations for clinical practice (2007). We compared surviving and non-surviving patients.
RESULTS: Fifty-six (56) cases were studied. The average age was 30 ± 11 years with a sex ratio of 6. Six cases had pulmonary disease. Neurological failure was present in 29 cases. Forty-seven cases were treated with quinine and 07 cases received norepinephrine. The length of stay was 3.55 ± 2.06 days. Eighteen subjects (32%) died. In multivariate analysis, neurological failure (p = 0.0001), jaundice (p = 0.0016), renal insufficiency (p <0.0001) and use of catecholamine (p = 0.0139) were associated with poor prognosis.
CONCLUSION: The mortality of malaria was high. Neurological failure, jaundice, renal insufficiency and use of catecholamine were poor prognostic factors.

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Author Biographies

Jasper Grant Raelison

Intensive Care Unit, University Hospital Center of Joseph Raseta Befelatanana, Antananarivo, Madagascar

Hanitra Mbolatiana Rivoarimanana

Intensive Care Unit Medical and Toxicological, University Hospital Center of Joseph Ravoahangy Andrianavalona, ​​Antananarivo, Madagascar

Tanjonirina Razafindrainibe

Surgical ICU, University Hospital Center of Joseph Ravoahangy Andrianavalona, ​​Antananarivo, Madagascar

Nadia Marie Philibertine Rahanitriniaina

Surgical ICU, University Hospital Center of Joseph Ravoahangy Andrianavalona, ​​Antananarivo, Madagascar

Falihery Albertin Rakotomavo

Intensive Care Unit, University Hospital Center of Joseph Raseta Befelatanana, Antananarivo, Madagascar

Nasolotsiry Enintsoa Raveloson

Intensive Care Unit, University Hospital Center of Joseph Raseta Befelatanana, Antananarivo, Madagascar

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CITATION
DOI: 10.26440/IHRJ/0307.10297
Published: 2019-10-24
How to Cite
1.
Jasper Grant Raelison, Hanitra Mbolatiana Rivoarimanana, Tanjonirina Razafindrainibe, Nadia Marie Philibertine Rahanitriniaina, Falihery Albertin Rakotomavo, Nasolotsiry Enintsoa Raveloson. Poor Prognosis Factors of Severe Malaria in Antananarivo, Madagascar. IHRJ [Internet]. 2019Oct.24 [cited 2024Mar.29];3(7):231-4. Available from: https://ihrjournal.com/ihrj/article/view/297

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