Oral Mucositis Induced by Methotrexate: A Case Report

  • Maya Verma
Keywords: Methotrexate, Rheumatoid Arthritis, Overdose, Toxicity


The prescription of Methotrexate is well-recognized for various neoplastic diseases. For Rheumatoid arthritis, it is prescribed once a week, low-dose regimen for the treatment of psoriasis and rheumatoid arthritis. Apart from providing therapeutic benefit, it is not devoid of side effects like oral ulceration which may be due to over dosage regarding its once-weekly regime. This case report describes a patient with inherent Methotrexate toxicity that developed oral mucositis due to Methotrexate being given for rheumatoid arthritis.


Download data is not yet available.


Saigal S, Singh RK, Poddar B. Acute methotrexate toxicity presenting as multiorgan failure and acute pneumonitis: A rare case report. Indian J Crit Care Med. 2012; 16(4): 225–7.

Weidmann A, Foulkes AC, Kirkham N, Reynolds N. Methotrexate toxicity during treatment of chronic plaque psoriasis: a case report and review of the literature. Dermatology and therapy. 2014;4(2):145–56.

Schmiegelow K. Advances in individual prediction of methotrexate toxicity: A review. Br J Haematol. 2009;46:489–503.

Drug Information for the Health Care Professional. 24 ed. Thomson Micromedex; 2004:pp1911.

Tan KW, Tay YK. A case of acute methotrexate toxicity. Ann Acad Med Singapore. 2011;40:97–9.

Gaies E, Jebabli N, Trabelsi S, Salouage I, Charfi R, et al. Methotrexate Side Effects: Review Article. J Drug Metab Toxicol 2012;3:125.

Howarda SC, McCormickb J, Puic CH, Buddingtona RK, Harveyd RD. Preventing and Managing Toxicities of High-Dose Methotrexate. The Oncologist 2016;21(12):1471-82.

Sonis ST. The pathobiology of mucositis. Nat Rev Cancer 2004;4:277-284.

Sonis ST. Mucositis as a biological process: A new hypothesis for the development of chemotherapy-induced stomatotoxicity. Oral Oncol 1998;34:39-43.

Sharma K. Managing Methotrexate Toxicity–A Case Report. Int Healthcare Res J 2017;1(1);28-32.

DOI: 10.26440/ihrj.v2i8.170
Published: 2018-11-24
How to Cite
Maya Verma. Oral Mucositis Induced by Methotrexate: A Case Report. IHRJ [Internet]. 2018Nov.24 [cited 2021Sep.25];2(8):195-6. Available from: https://ihrjournal.com/ihrj/article/view/170