Benign Mucous Membrane Pemphigoid: A Case Report

Keywords: Autoimmune Disease, Pemphigoid, Mucous Membrane


Benign Mucous Membrane Pemphigoid (MMP) is a vesiculobullous (VB) lesion that affects oral and nasal mucosa, oropharynx, conjunctiva, and genital mucosa. It is considered an autoimmune disease. Autoantibodies are produced due to several external factors or genetic factors. It creates many complications, such as defects in vision, voice alteration (hoarseness), airway obstruction, and dyspareunia. The subepithelial blisters form due to these antibodies. Treatment modalities differ from topical steroids to systemic steroid therapy based on the nature and severity of clinical symptoms.


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Author Biographies

Nidhi Ojha

Ex-PG student, Dept of Oral and Maxillofacial Pathology, Modern Dental College, Indore, Currently based in  Athens, Ohio, USA

Om Prakash Yadav

Graduate Student (M.Sc. in Medicine (Community Health), Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, NL, Canada)


Rastogi V, Sharma R, Misra S, Yadav L. Diagnostic procedures for autoimmune vesiculobullous diseases: A review. J Oral Maxillofac Pathol.2014;18(3):390.

Laskaris G. 2nd ed. Ch 4. Georg Thieme Verlag. Pocket atlas of oral diseases; 2006 pp. 101–6.

Xu HH, Werth VP, Parisi E, Sollecito TP. Mucous membrane pemphigoid. Dent Clin North Am.2013;57:611–30.

Dear JW, Lilitkarntakul P, Webb DJ. Are rare diseases still orphans or happily adopted? The challenges of developing and using orphan medicinal products. Br J Clin Pharmacol.2006;62:264–71.

Bruch-Gerharz D, Hertl M, Ruzicka T. Mucous membrane pemphigoid: Clinical aspects, immunopathological features and therapy. Eur J Dermatol.2007;17:191–200.

Schmidt E, Zillikens D. Pemphigoid diseases. Lancet.2013;381:320–32.

Scully C, Carrozzo M, Gandolfo S, Puiatti P, Monteil R. Update on mucous membrane pemphigoid: A heterogeneous immune-mediated subepithelial blistering entity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.1999;88:56–68.

Wickmanns JE. Ideas on the diagnosis. Vol. 1. Hanover: Helwig;1894. p. 89.

Delgado JC, Turbay D, Yunis EJ, Yunis JJ, Morton ED, Bhol K, et al. A common major histocompatibility

complex Class II allele HLA-DQB1*0301 is present in clinical variants of pemphigoid. Proc Natl Acad Sci U S A.1996;93:8569-71.

Scully C, Lo Muzio L. Oral mucosal diseases: Mucous membrane pemphigoid. Br J Oral Maxillofac Surg.2008;46:358–66.

Sami N, Bhol KC, Ahmed AR. Treatment of oral pemphigoid with intravenous immunoglobulin as monotherapy. Long-term follow-up: Influence of treatment on antibody titres to human alpha6 integrin. Clin Exp Immunol.2002;129:533–40.

Ata-Ali F, Ata-Ali J. Pemphigus vulgaris and mucous membrane pemphigoid: update on etiopathogenesis, oral manifestations and management. J Clin Exp Dent.2011;3(3):e246-250.

Mostafa MI, Hassib NF, Nemat AH. Oral mucous membrane pemphigoid in a 6-year-old boy: diagnosis, treatment and 4 years follow-up. Int J Paediatr Dent.2010;20(1):76-79.

Schifter M, Yeoh SC, Coleman H, Georgiou A. Oral mucosal diseases: the inflammatory dermatoses. Aust Dent J.2010;55(Suppl 1):23-38.

Rajendran R, Sivapathasundharam B. Shafer’s Textbook of Oral Pathology; Elsevier: 6th ed; 2009. p. 822.

Gagari E, Damoulis PD. Desquamative gingivitis as a manifestation of chronic mucocutaneous disease. JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2010;9(3):184–7.

Bagan J, Lo Muzio L, Scully C. Mucosal disease series— number III: mucous membrane pemphigoid. Oral Dis.2005;11:197-218.

Arvind Babu RS, Chandrasekar P, Chandra KL, Reddy GS, Kumar KK, Ramana Reddy BV. Immunofluorescence and its application in dermatopathology with oral manifestations: Revisited. J Orofac Sci.2013;5:2-8.

DOI: 10.26440/IHRJ/0402.05333
Published: 2020-05-21
How to Cite
Nidhi Ojha, Om Prakash Yadav. Benign Mucous Membrane Pemphigoid: A Case Report. IHRJ [Internet]. 2020May21 [cited 2021Jul.30];4(2):34-7. Available from: