Antiepileptics and Sound Perception Disorders

  • Ashwani Bhasker
Keywords: Epilepsy, Sound, Perception


Epilepsy, a neurological health issue has been reported in all age groups and all countries. Anti-epileptic drugs have been reported to have many adverse events affecting different body parts and organs but their hazardous affect on a primary sensory organ is less known. In this mini review, we discuss thee impact of anti-epileptic medications on sound perception which adversely disrupts the quality of life.


Download data is not yet available.

Author Biography

Ashwani Bhasker

MBBS, Private Practitioner, Parwanoo, Himachal Pradesh


1. Sankaraneni R, Lachhwani D. Antiepileptic drugs - A review. Pediatr Ann. 2015;44(2):e36-42.
2. Borrelli EP, Lee EY, Descoteaux AM, Kogut SJ, Caffrey AR. Stevens-Johnson syndrome and toxic epidermal necrolysis with antiepileptic drugs: an analysis of the US Food and Drug Administration Adverse Event Reporting System. Epilepsia 2018;59(12):2318-24.
3. Berghuis B, van der Palen J, de Haan GJ, Lindhout D, Koeleman BPC, Sander JW, et al. Carbamazepine- and oxcarbazepine- induced hyponatremia in people with epilepsy. Epilepsia 2017;58(7):1227-33.
4. Mohan RPS, Rastogi K, Bhushan R, Verma S. Phenytoin-induced gingival enlargement: a dental awakening for patients with epilepsy. BMJ Case Rep. 2013;2013.
5. Weston J, Bromley R, Jackson CF, Adab N, Clayton-Smith J, Greenhalgh J, et al. Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child. Cochrane Database Syst Rev. 2016;11:CD010224.
6. Bentué-Ferrer D, Verdier MC, Tribut O. Pharmacological therapeutic follow-up of primidone and phenobarbital. Therapie 2012;67 (4):381—90.
7. Zaccara G, Perucca E. Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs. Epileptic Disord. 2014;(4):409—31.
8. Patsalos PN, Berry DJ, Bourgeois BFD, Cloyd JC, Glauser TA, Johannessen SI, et al. Antiepileptic drugs best practice guidelines for therapeutic drug monitoring: a position paper by the sub commission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008;49(7):1239-76.
9. Brodie MJ, Besag F, Ettinger AB, MulaM, Gobbi G, Comai S, et al. Epilepsy, antiepileptic drugs, and aggression: an evidence based review. Pharmacol Rev. 2016;68(3):563-602.
10. Hamed SA. The auditory and vestibular toxicities induced by antiepileptic drugs. Expert Opin Drug Saf. 2017;16(11):1281-94.
11. Tateno A, Sawada K, Takahashi I, Hujiwara Y. Carbamazepine- induced transient auditory pitch-perception deficit. Pediatr Neurol. 2006;35(2):131-4.
12. Gur-Ozmen S, Nirmalananthan N, von Oertzen TJ. Change of pitch due to carbamazepine and oxcarbazepine independently. Seizure 2013;22(2):162-3.
13. Maguire MJ. Music and epilepsy: a critical review: music and epilepsy. Epilepsia 2012;53(6):947-61.
14. Kawai M, Kanemoto K. A case of auditory disturbance caused by lacosamide. Epilepsy Behav Case Rep. 2019;11:70-2.
DOI: 10.26440/IHRJ/0402.05347
Published: 2020-05-24
How to Cite
Ashwani Bhasker. Antiepileptics and Sound Perception Disorders. IHRJ [Internet]. 2020May24 [cited 2022May25];4(2):28-0. Available from: