Effectiveness Of 1.2% Simvastatin Gel as an Adjunct to Non-Surgical Therapy in The Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Trial

Keywords: Simvastatin, Local Drug Delivery, Chronic Periodontitis, Inflammation, Statins

Abstract

BACKGROUND: Periodontitis is an inflammatory disease that results in bone resorption creating bony defects, which may cause tooth loss.
AIM: The present study aimed to evaluate the effectiveness of 1.2% Simvastatin gel as an adjunct to non-surgical therapy to treat chronic periodontitis (CP).
MATERIALS AND METHOD: 25 patients with 50 sites were categorized into two treatment groups: Scaling and Root Planing plus 1.2% Simvastatin, and Scaling and Root Planing with placebo. Clinical parameters; site-specific plaque index, modified sulcus bleeding index (mSBI), pocket probing depth (PD), and relative attachment level (RAL) were recorded at baseline, 3, 6, and 9 months.
RESULTS: Mean PD reduction and mean RAL gain was found to be greater in Simvastatin group than the placebo group, at 3, 6, and 9 months.
CONCLUSION: Locally delivered Simvastatin was found to be effective in the treatment of chronic periodontitis (CP).

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Author Biographies

Neetika Gupta

Postgraduate Student, Department of Periodontics, I.T.S Dental College, Hospital & Research Centre, Greater Noida

Sherry Verma

Junior Resident, K.D. Dental College, Hospital & Research Centre, Mathura

Siddharth Sharma

Junior Resident, I.T.S Dental College, Hospital & Research Centre, Greater Noida

Jaipreet Singh Gill

Junior Resident, I.T.S Dental College, Hospital & Research Centre, Greater Noida

Aman Khurana

Graduate student, I.T.S Dental College, Hospital &Research Centre, Greater Noida

Stuti Gupta

Assistant Professor, Department of Periodontology, School of Dental Sciences, Sharda University, Greater Noida

Tauqeer-Ul-Nisa

Postgraduate Student, Department of Periodontics, I.T.S Dental College, Hospital & Research Centre, Greater Noida

Arushi Dewan

Postgraduate Student, Department of Periodontics, I.T.S Dental College, Hospital & Research Centre, Greater Noida

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CITATION
DOI: 10.26440/IHRJ/0412.03396
Published: 2021-03-23
How to Cite
1.
Neetika Gupta, Sherry Verma, Siddharth Sharma, Jaipreet Singh Gill, Aman Khurana, Stuti Gupta, Tauqeer-Ul-Nisa, Arushi Dewan. Effectiveness Of 1.2% Simvastatin Gel as an Adjunct to Non-Surgical Therapy in The Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Trial. IHRJ [Internet]. 2021Mar.23 [cited 2021Sep.22];4(12):OR1-OR6. Available from: https://ihrjournal.com/ihrj/article/view/396