Effectiveness Of 1.2% Simvastatin Gel as an Adjunct to Non-Surgical Therapy in The Treatment of Chronic Periodontitis: A Split Mouth Randomized Controlled Trial
Abstract
BACKGROUND: Periodontitis is an inflammatory disease that results in bone resorption creating bony defects, which may cause tooth loss.
AIM: The present study aimed to evaluate the effectiveness of 1.2% Simvastatin gel as an adjunct to non-surgical therapy to treat chronic periodontitis (CP).
MATERIALS AND METHOD: 25 patients with 50 sites were categorized into two treatment groups: Scaling and Root Planing plus 1.2% Simvastatin, and Scaling and Root Planing with placebo. Clinical parameters; site-specific plaque index, modified sulcus bleeding index (mSBI), pocket probing depth (PD), and relative attachment level (RAL) were recorded at baseline, 3, 6, and 9 months.
RESULTS: Mean PD reduction and mean RAL gain was found to be greater in Simvastatin group than the placebo group, at 3, 6, and 9 months.
CONCLUSION: Locally delivered Simvastatin was found to be effective in the treatment of chronic periodontitis (CP).
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References
Laine ML, Crielaard W, Loos BG. Genetic susceptibility to periodontitis. Periodontol. 2000 2012;58:37–68.
Blake GJ, Ridker PM. Are statins anti-inflammatory? Curr Control Trials Cardiovasc Med. 2000;1:161–5.
Kirmizis D, Chatzidimitriou D. Pleiotropic vasoprotective effects of statins: the chicken or the egg? Drug Des Dev Ther. 2009;3:191–204.
Shishehbor MH, Brennan ML, Aviles RJ, et al. Statins promote potent systemic antioxidant effects through specific inflammatory pathways. Circulation 2003;108:426–431.
Davignon J. Beneficial cardiovascular pleiotropic effects of statins. Circulation 2004;109:III39–43.
Laufs U, Liao JK. Isoprenoid metabolism and the pleiotropic effects of statins. Curr Atheroscler Rep. 2003;5:372–8.
Nagashima H, Aoka Y, Sakomura Y, et al. A 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, cerivastatin, suppresses production of matrix metalloproteinase-9 in human abdoabdominal aortic aneurysm wall. J Vasc Surg. 2002;36:158–163.
Ohnaka K, Shimoda S, Nawata H, et al. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun. 2001;287:337–342.
Mundy G, Garrett R, Harris S, et al. Stimulation of bone formation in vitro and in rodents by statins. Science 1999; 286:1946–9.
Lindy O, Suomalainen K, Makela M, Lindy S. Statin use is associated with fewer periodontal lesions: a retrospective study. BMC Oral Health 2008;8:16.
Sakoda K, Yamamoto M, Negishi Y, Liao JK, Node K,Izumi Y. Simvastatin decreases IL-6 and IL-8 production in epithelial cells. J Dent Res. 2006;85:520-523.
Pradeep AR, Thorat MS. Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial. J Periodontol. 2010;81:214–22.
Pradeep AR, Priyanka N, Kalra N, Naik SB, Singh SP, Martande S. Clinical efficacy of subgingivally delivered 1.2-mg simvastatin in the treatment of individuals with class II furcation defects: a randomized controlled clinical trial. J Periodontol. 2012;83:1472–9.
Rao NS, Pradeep AR, Bajaj P, Kumari M, Naik SB. Simvastatin local drug delivery in smokers with chronic periodontitis: a randomized controlled clinical trial. Aust Dent J. 2013;58:156–62.
Fento_gluO¨, Bozkurt FY. The bi-directional relationship between periodontal disease and hyperlipidemia. Eur J Dent. 2008;2:142-146.
Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol. 2001;21:1712-1719.
Fentoglu O¨, Ko¨roglu BK, Hicxyılmaz H, et al. Proinflammatory cytokine levels in association between periodontal disease and hyperlipidaemia. J Clin Periodontol. 2011;38:8-19.
Fento_glu O, So¨zen T, Oz SG, et al. Short-term effects of periodontal therapy as an adjunct to anti-lipemic treatment. Oral Dis. 2010;16:648-54.
Sharma A, Pradeep AR. Clinical efficacy of 1% alendronate gel as local drug delivery system in the treatment of chronic periodontitis – A Randomized Controlled Clinical Trial. J Periodontol. 2012;83:11–8.

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