Anaphylactic Reactions to COVID-19 Vaccine

Abstract

The SARS-CoV-2 coronavirus responsible for the COVID-19 pandemic has led to a major health crisis and high mortality rates. Progression to a severe and potentially fatal form of COVID-19 is associated not only with massive viral replication, but also with an inappropriate inflammatory response against the SARS-CoV-2 virus. Therefore, drug strategies may target not only the viral infection itself, but also inappropriate immunoinflammatory responses. Numerous wide-ranging medications have been attempted to improve the prognosis and outcome of COVID-19, especially among hospitalized patients due to an acute respiratory distress syndrome. Vaccination against COVID-19 is an essential global intervention to control the current pandemic situation. Vaccines often cause adverse events; however, the vast majority of adverse events following immunization are due to the protective immune response induced by the vaccine, and not due to an allergic reaction. It is important to know that how can SARS-CoV-2 vaccines be administered with minimal risk of allergic reactions. In fact, currently available mRNA vaccines may usually be administered readily even to patients with allergies. The following review describes the risk of severe anaphylaxis and provides practical tips for safe vaccination.