The Association between Vaccination and Autoimmunity
Vaccines are one of the prime preventive measures against infectious diseases. Administration of vaccination may lead to significant autoimmune manifestations. There is a vast literature on autoimmune issues associated with vaccines including animal and in-vitro studies, case reports and case series. Contrary to this, epidemiological research work does not report this association. This review on the potential association between vaccines and the development of autoimmune diseases is based on currently available scientific literature. We conclude that vaccines have a very positive impact on human health. Further research is required to clarify the association between vaccines and autoimmune conditions and also the detailed mechanisms behind this.
Rose NR. Autoimmunity, infections and adjuvants. Lupus. 2010;19(4):354-8.
Orbach H, Shoenfeld Y. Vaccination, infection and autoimmunity: myth and reality VIAMR 2005-10-26-28, Beau-Rivage Palace Hotel, Lausanne, Switzerland. Autoimmunity Rev. 2007(6):261-6.
Chen RT, Pless R, DeStefano F. Epidemiology of autoimmune reactions induced by vaccination. J Autoimmun. 2001;16(3):309-18.
Alvord EC, Kies MW, Suckling AJ. Experimental allergic encephalomyelitis: a useful model for multiple sclerosis. In : Alvord EC, Kies MW, Suckling AJ (Eds). Progress in Clinical and Biological Research. New York; Alan R Liss Inc; 1984. p. 523-37.
Burkhardt H, Kalden JR. Animal models of autoimmune diseases. Rheumatol Int. 1997;17(3):91-9.
Oldstone MB. Molecular mimicry and immune-mediated diseases. FASEB J. 1998;12(13):1255-65.
Geier DA, Geier MR. Hepatitis B vaccination and arthritic adverse reactions: a follow-up analysis of the Vaccine Adverse Events Reporting System (VAERS) database. Clin Exp Rheumatol. 2002;20(1):119.
Herroelen L, de Keyser J, Ebinger G. Central-nervoussystem demyelination after immunisation with recombinant hepatitis B vaccine. Lancet. 1991;338(8776):1174-5.
Gout O, Lyon-Caen O. Sclerotic plaques and vaccination against hepatitis B. Rev Neurol (Paris). 1998;154(3):205-7.
Vial T, Descotes J. Autoimmune diseases and vaccinations. Eur J Dermatol. 2004;14(2):86-90.
Duclos P. Safety of immunization and adverse events following vaccination against hepatitis B. Expert Opin Drug Saf. 2003;2(3):225-31.
Schattner A. Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines. Vaccine. 2005;23(30):3876-86.
Girard M. Autoimmune hazards of hepatitis B vaccine. Autoimmun Rev. 2005;4(2):96-100.
Bogdanos DP, Smith H, Ma Y, Baum H, Mieli-Vergani G, Vergani D. A study of molecular mimicry and immunological cross-reactivity between hepatitis B surface antigen and myelin mimics. Clin Dev Immunol. 2005;12(3):217-24.
Vento S, Garofano T, Di Perri G, Dolci L, Concia E, Bassetti D. Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals. Lancet. 1991;337(8751):1183-7.
Haber P, DeStefano F, Angulo FJ, Iskander J, Shadomy SV, Weintraub E, et al. Guillain–Barré syndrome following influenza vaccination. JAMA. 2004;292(20):2478-81.
Schoenberger LB, Bregman DJ, Sullivan-Bolyai JZ, Keenlyside RA, Ziegler DW, Retailliau HF, et al. Guillain–Barre syndrome following vaccination in the National Influenza Immunization Program, United States, 1976-1977. Am J Epidemiol. 1979;110(2):105-23.
Lasky T, Terracciano Gj, Madger L, Koski CL, Ballesteros M, Nash D, et al. The Guillain–Barré syndrome and the 1992-1993 and 1993-1994 influenza vaccines. N Engl J Med. 1998;339(25):1797-802.
Geier MR, Geier DA, Zahalsky AC. Influenza vaccination and Guillain Barre syndrome small star, filled. Clin Immunol. 2003;107(2):116-21.
Childhood immunizations and type 1 diabetes: summary of an Institute for Vaccine Safety Workshop. The Institute for Vaccine Safety Diabetes Workshop Panel. Pediatr Infect Dis J. 1999;18(3):217-22.
Karvonen M, Cepaitis Z, Tuomilehto J. Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study. BMJ. 1999;318(7192):1169-72.
Thomas RE, Lorenzetti DL, Spragins W, Jackson D, Williamson T. Active and passive surveillance of yellow fever vaccine 17D or 17DD-associated serious adverse events: systematic review. Vaccine. 2011;29(28):4544-55.
Barrett AD, Teuwen DE. Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? Curr Opin Immunol. 2009;21(3):308-13.
Khromava AY, Eidex RB, Weld LH, Kohl KS, Bradshaw RD, Chen RT, et al. Yellow fever vaccine: an updated assessment of advanced age as a risk factor for serious adverse events. Vaccine. 2005;23(25):3256-63.
Braun J, Bollow M, Remlinger G, Eggens U, Rudwaleit M, Distler A, et al. Prevalence of spondyloarthropathies in HLA-B27 positive and negative blood donors. Arthritis Rheum. 1998; 41(1):58-67.
Pitkanen J, Peterson P. Autoimmune regulator: from loss of function to autoimmunity. Genes Immun. 2003;4(1):12-21.
Anderson AC, Anderson DE. TIM-3 in autoimmunity. Curr Opin Immunol. 2006;18(6):665-9.
Batista-Duharte A, Lindblad EB, Oviedo-Orta E. Progress in understanding adjuvant immunotoxicity mechanisms. Toxicol Lett. 2011;203(2):97-105.
Waisbren BA Sr. Acquired autoimmunity after viral vaccination is caused by molecular mimicry and antigen complimentarity in the presence of an immunologic adjuvant and specific HLA patterns. Med Hypotheses. 2008;70(2):346-8.
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