Drug Interactions: A Review
Abstract
Increased use of drugs as well as polypharmacy has led to increase in incidence of drug interactions. These interactions may lead to medically significant as well as life threatening complications. Not all kind of interactions that can occur with a drug are known. The data in reference safety documents, published literature and safety databases is also limited. Some drugs may also react to certain foods or beverages if taken concomitantly. Most of the interactions come into picture during post-marketing phase of a drug. Latest versions of labelling documents by the manufacturers are informative but not necessarily for newly approved drugs. It is imperative for the healthcare professionals to check for known interactions while prescribing multiple drugs. Detailed diet routine and ongoing medications of subjects also need to be taken into consideration.
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