Vancomycin Induced Nephrotoxicity: A Case Report

  • Santoshini Naveen
  • Peter Jensen
Keywords: Vancomycin, Nephrotoxicity, Renal Dysfunction

Abstract

Nephrotoxicity associated with vancomycin is a commonly feared and mainly preventable adverse effect. Non-severe cases of vancomycin nephrotoxicity resolve upon discontinuation of the medication. We present the case of a 45-year-old man who developed renal dysfunction following vancomycin antibiotic therapy as a result of lack of dose adaptation to measured serum nadirs.

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Author Biographies

Santoshini Naveen

MD (Medicine), Consultant Private Practitioner and Independent Researcher, Navi Mumbai, India

Peter Jensen

MD (Medicine), Consultant Practitioner, Randers, Denmark

References

Rybak MJ, Albrecht LM, Boike SC, Chandrasekar PH. Nephrotoxicity of vancomycin, alone and with an aminoglycoside. J Antimicrob Chemother. 1990;25(4):679-87. https://doi.org/10.1093/jac/25.4.679.

Rybak M, Lomaestro B, Rotschafer JC, Moellering R Jr, Craig W, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009;66(1):82-98. https://doi.org/10.2146/ajhp080434.

Rybak MJ, Lomaestro BM, Rotschafer JC, Moellering RC, Craig WA, et al. Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. Clin Infect Dis. 2009;49(3):325-7. https://doi.org/10.1086/600877.

Burgess LD, Drew RH. Comparison of the incidence of vancomycin-induced nephrotoxicity in hospitalized patients with and without concomitant piperacillin-tazobactam. Pharmacotherapy. 2014;34(7):670-6. https://doi.org/10.1002/phar.1442.

CITATION
DOI: 10.26440/0602.05540
Published: 2022-05-31
How to Cite
1.
Santoshini Naveen, Peter Jensen. Vancomycin Induced Nephrotoxicity: A Case Report. IHRJ [Internet]. 2022May31 [cited 2022Jul.2];6(2):CR1-CR2. Available from: https://ihrjournal.com/ihrj/article/view/540