Skin Reaction to an Asthmatic Patient on Hydrocortisone

  • Abby Wong
  • Carlson James
  • Manika Sharma
Keywords: Pruritis, Hydrocortisone, Skin Reaction


Steroids constitute the basic of treatment of asthma by interrupting the development of inflammation. Although being prescribed to subjects for allergies, they can also be the culprit behind allergic reactions. We report a case of a 38-year-old woman, who was prescribed hydrocortisone for severe acute asthma, and presented with an allergy to hydrocortisone in the form of generalized pruritus, cutaneous mucosal lesions in the form of purpura and ecchymoses on the abdomen and limbs. The substitution of hydrocortisone led to recovery.


Download data is not yet available.

Author Biographies

Abby Wong

MD (Dermatology), Private Practitioner, Alberta, Canada

Carlson James

MD (Dermatology), Private Practitioner, Alberta, Canada

Manika Sharma

MBBS, Private Practitioner, Pune, India.


Barnes N. Relative safety and efficacy of inhaled corticosteroids. J Allergy Clin Immunol. 1998;101:S460-S464.

Beynel P, Guerin JC. Anaphylactic reactions to systemic corticosteroids. Review of the literature concerning 3 cases. Rev Mal Respir. 1999; 16:529-37.

Miltgen J, Marotel C, Natali F, Vaylet F, L’her P. Clinical aspects and diagnosis of sulfite intolerance. Apropos of 9 patients. Rev Pneumol Clin. 1996;52:363-71.

Judson MA, Sperl PL. Stacus asthmaticus with acute decompensation with therapy in à 27 year old woman. Chest 1995; 107: 563-4.

Nakamura H, Matsuse H, Obase Y et al. Clinical evaluation of anaphylactic reactions to intravenous corticosteroids in adult asthmatics. Respiration 2002; 69:309-13.

Figueredo E, Cuesta-Herranz J, De las Heras M, Lluch-Bernal M, Umpierrez A, Sastre J. Anaphylaxis to dexamethasone. Allergy 1997; 52:877.

Velasquez E, Escribano M, Gonzalez Pol J et al. Adverse reaction to systemic corticoids. Allergy 1997;51: 317.

Al Mahdy H, Hall M. Anaphylaxis and hydrocortisone. Ann Intern Med. 1988;108:487-8.

Prabhu SL. Fatal systemic reaction following intramusculaire solumedrol and depomedrol. J Allergy Clin Immunol 1997; 99:435.

Clark RJ. Exacerbation of asthma after nebulized beclomethasone dipropionate. Lancet 1986; ii : 574-5.

Shim CS, Williams MH. Cough and wheezing from beclomethasone aerosol. Chest 1987; 91: 207-9.

Moreno-Ancillo A, Martin-Munoz F, Martin-Barroso JA, Diaz-Pena JM, Ojeda JA. Anaphylaxis to a 6-alpha- methylprednisolone in an eight-year-old child. J Allergy Clin Immunol 1997;97:1169-71.

Peris-Tortajada A, Giner A, Perez C, Hernandez D, Basomba A. Contact allergy to topical budesonide. J Allergy Clin Immunol 1991;78:597-8.

Escribano-Rodriguez M, Gonzales-Pol J, Munoz-Bellido F, de la Calle- Toral A, Velasquez-Amor E, Conde-Hernandez J. Immediate reaction to methylprednisolone with tolerance of other corticoids. Allergy 1997;52:677-8.

Fernandez S, Reano M, Vives R et al. 6-methylprednisolone induced bronchospsam. Allergy 1997;52:780-2.

Freedman MD, Schocket AL, Chapel N, Gerber JG. Anaphylaxis after intravenous methylprednisolone administration. JAMA 1981;245:607-8.

Vally H, Thomson PJ. Role of sulfite additives in wine induced asthma: single dose and cumulative dose studies. Thorax 2001;56:763-9.

Partridge MR, Gibson GJ. Adverse bronchial reactions to intravenous hydrocortisone in two aspirin-sensitive asthmatic patients. BMJ 1978;521-2.

DOI: 10.26440/IHRJ/0611.02595
Published: 2023-03-12
How to Cite
Abby Wong, Carlson James, Manika Sharma. Skin Reaction to an Asthmatic Patient on Hydrocortisone. IHRJ [Internet]. 2023Mar.12 [cited 2023Mar.29];6(11):RV4-RV6. Available from: